Publications of Maria Blasco portal 01-24-2014d0934

2015-01-13

Publications of Maria Blasco portal 01-24-2014d0934

61 papers in the last 5 years

word cloud on notes from papers over the last 5 years
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2014\02-09-2014d1516\blasco\word cloud on notes for blasco papers from 2009 to 2013 with color.PNG"

all of the publications in one folder as well as all of the publications in a single pdf file (about 630 pages) can be found here
C:\Users\kurtw_000\Documents\kurt\storage\DR\2014\05-15-2014d1147\blasco publications 2009-2014 one folder

notes from papers over the last 5 years combined into one document
-notes on blasco papers from 2009 to 2013 combined

papers I may want to request from interlibrary loan:
-Suv4-20h Abrogation Enhances Telomere Elongation during Reprogramming and Confers a Higher Tumorigenic Potential to iPS Cells
-Telomeres and telomerase in adult stem cells and pluripotent embryonic stem cells
-Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases
--requested document from ill asu on 02-09-2014d1533
--received item 2-11-14
-TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells
--requested document from ill asu on 02-09-2014d1533
--received item 2-11-14


one significant publication in 2008 (not in last five years)
-Telomerase reverse transcriptase delays aging in cancer­resistant mice

Key papers
-Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
-Telomerase reverse transcriptase delays aging in cancer­resistant mice

Two of my favorite review papers from these 5 years
-Potential of telomerase activation in extending health span and longevity
-Telomeres in cancer and ageing (royal society review paper)
I also liked
-The hallmarks of aging


-POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia
--Ramsay AJ, Quesada V, Foronda M, Conde L, Martínez-Trillos A, Villamor N, Rodríguez D, Kwarciak A, Garabaya C, Gallardo M, López-Guerra M, López-Guillermo A, Puente XS, Blasco MA, Campo E, López-Otín C (2013). POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia. Nat Genet 45, 526-530.
-The hallmarks of aging
--López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013). The hallmarks of aging. Cell 153, 1194-1217.
-p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes
--Mondal AM, Horikawa I, Pine SR, Fujita K, Morgan KM, Vera E, Mazur SJ, Appella E, Vojtesek B, Blasco MA, Lane DP, Harris CC (2013). p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. J Clin Invest 123, 5247-5257.
-TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells
--Schneider RP, Garrobo I, Foronda M, Palacios JA, Marión RM, Flores I, Ortega S, Blasco MA (2013). TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells. Nat Communications (in press).
-Telomerase at the intersection of cancer and aging
--Bernardes de Jesus B, Blasco MA (2013). Telomerase at the intersection of cancer and aging. Trends Genet 29, 513-520.
-Telomere Length and Telomerase Activity Impact the UV Sensitivity Syndrome Xeroderma Pigmentosum
--Stout GJ, Blasco MA (2013). Telomere Length and Telomerase Activity Impact the UV Sensitivity Syndrome Xeroderma Pigmentosum C. Cancer Res 73, 1844-1854.
-A metabolic signature predicts biological age in mice
--Tomás-Loba A, Bernardes de Jesus B, Mato JM, Blasco MA (2013). A metabolic signature predicts biological age in mice. Aging Cell 12, 93-101.
-Short telomeres are frequent in hereditary breast tumors and are associated with high tumor grade
--Martinez-Delgado B, Gallardo M, Tanic M, Yanowsky K, Inglada-Perez L, Barroso A, Rodriguez-Pinilla M, Cañamero M, Blasco MA, Benitez J (2013). Short telomeres are frequent in hereditary breast tumors and are associated with high tumor grade. Breast Cancer Res Treat 141, 231-242.
-Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity
--Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA (2013). Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. PLoS ONE 8, E53760-.
-Interview: Fighting disease from the chromosome end
--Blasco MA (2013). Interview: Fighting disease from the chromosome end. Epigenomics 5, 483-485.
-RAP1 protects from obesity through its extratelomeric role regulating gene expression
--Martínez P, Gómez-López G, García F, Mercken E, Mitchell S, Flores JM, De Cabo R, Blasco MA (2013). RAP1 protects from obesity through its extratelomeric role regulating gene expression. Cell Reports 3, 2059-2074.
-Localization-dependent and -independent roles of SLX4 in regulating telomeres
--Wilson JS, Tejera AM, Castor D, Toth R, Blasco MA, Rouse J (2013). Localization-dependent and -independent roles of SLX4 in regulating telomeres. Cell Reports 4, 853-860.
-Personal omics profiling reveals dynamic molecular and medical phenotypes
--Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M (2012). Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 148, 1293-1307.
-A subpopulation of adult skeletal muscle stem cells retains all template DNA strands after cell division
--Rocheteau P, Gayraud-Morel B, Siegl-Cachedenier I, Blasco MA, Tajbakhsh S (2012). A subpopulation of adult skeletal muscle stem cells retains all template DNA strands after cell division. Cell 148, 112-125.
-Assessing cell and organ senescence biomarkers
--Bernardes de Jesus B, Blasco MA (2012). Assessing cell and organ senescence biomarkers. Circ Res 111, 97-109.
-Potential of telomerase activation in extending health span and longevity
--Bernades de Jesus B, Blasco MA (2012). Potential of telomerase activation in extending health span and longevity. Curr Opin Cell Biol 24, 739-743.
-53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response
--Martínez P, Flores JM, Blasco MA (2012). 53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response. J Cell Biol 197, 283-300.
-Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion
--Ganuza M, Sáiz-Ladera C, Cañamero M, Gómez G, Schneider R, Blasco MA, Pisano DG , Paramio JM, Santamaría D, Barbacid M (2012). Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. EMBO J 31, 2498-2510.
-Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres
--Remeseiro S, Cuadrado A, Carretero M, Martínez P, Drosopoulos WC, Cañamero M, Schildkraut CL, Blasco MA, Losada A (2012). Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. EMBO J 31, 2076-2089.
-Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma
--Andoniadou CL, Gaston-Massuet C, Reddy R, Schneider RP, Blasco MA, Le Tissier P, Jacques TS, Pevny LH, Dattani MT, Martinez-Barbera JP (2012). Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma. Acta Neuropathol 124, 259-271.
-Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of Dyskeratosis congenita
--Beier F, Foronda M, Martinez P, Blasco MA (2012). Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of Dyskeratosis congenita. Blood 120, 2990-3000.
-Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
--Bernardes de Jesus B, Vera E, Schneeberger K, Tejera AM, Ayuso E, Bosch F, Blasco MA (2012). Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med 4, 691-704.
-Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases
--Martinez-Delgado B, Yanowsky K, Inglada-Perez L, de la Hoya M, Caldes T, Vega A, Blanco A, Martin T, Gonzalez-Sarmiento R, Blasco MA, Robledo M, Urioste M, Song H, Pharoah P, Benitez J (2012). Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases. J Med Genet 49, 341-344.
-Beyond average c potential for measurement of short telomeres
--Vera E, Blasco MA (2012). Beyond average: potential for measurement of short telomeres. Aging (Albany NY) 4, 379-392.
-The Rate of Increase of Short Telomeres Predicts Longevity in Mammals
--Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA (2012). The Rate of Increase of Short Telomeres Predicts Longevity in Mammals. Cell Reports 2, 732-737.
-Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
--Martínez P, Blasco MA (2011). Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat Rev Cancer 11, 161-176.
-Aging by telomere loss can be reversed
--Bernardes de Jesus B, Blasco MA (2011). Aging by telomere loss can be reversed. Cell Stem Cell 8, 3-4.
-Isolation and in vitro expansion of human colonic stem cells
--Jung P, Sato T, Merlos-Suárez A, Barriga FM, Iglesias M, Rossell D, Gallardo MM, Blasco MA, Sancho E, Clevers H, Batlle E (2011). Isolation and in vitro expansion of human colonic stem cells. Nat Med 17, 1225-1227.
-Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes
--Martin D, Pantoja C, Fernández Miñán A, Valdes-Quezada C, Moltó E, Matesanz F, Bogdanovic O, de la Calle-Mustienes E, Domínguez O, Taher L, Furlan-Magaril M, Alcina A, Cañón S, Fedetz M, Blasco MA, Pereira PS, Ovcharenko I, Recillas-Targa F, Montoliu L, Manzanares M, Guigó R, Serrano M, Casares F, Gómez-Skarmeta JL (2011). Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes. Nat Struct Mol Biol 18, 708-714.
-Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells
--Varela E, Schneider RP, Ortega S, Blasco MA (2011). Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells. Proc Natl Acad Sci USA 108, 15207-15212.
-Genomic instability in iPS: time for a break
--Blasco MA, Serrano M, Fernandez-Capetillo O (2011). Genomic instability in iPS: time for a break. EMBO J 30, 991-993.
-Telomeres in cancer and ageing
--Donate LE, Blasco MA (2011). Telomeres in cancer and ageing. Philos T Roy Soc B 366, 76-84.
-The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence (*I've read this paper in the past)
--de Jesus BB, Schneeberger K, Vera E, Tejera A, Harley CB, Blasco MA (2011). The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell 10, 604-621.
--"C:\Users\kurtw_000\Box Sync\DocDR\2014\04-01-2014d0915\The telomerase activator TA-65 elongates short telomeres and increases health span of adult old mice without increasing cancer incidence.pdf"
-Suv4-20h Abrogation Enhances Telomere Elongation during Reprogramming and Confers a Higher Tumorigenic Potential to iPS Cells
--Marión RM, Schotta G, Ortega S, Blasco MA (2011). Suv4-20h Abrogation Enhances Telomere Elongation during Reprogramming and Confers a Higher Tumorigenic Potential to iPS Cells. PLoS ONE 6, e25680-e25680.
-The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder
--Elvsåshagen T, Vera E, Bøen E, Bratlie J, Andreassen OA, Josefsen D, Malt UF, Blasco MA, Boye B (2011). The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder. J Affect Disorders 135, 43-50.
-Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites
--Martinez P, Thanasoula M, Carlos Ana R, Gómez- Lopez G, Tejera AM, Schoeftner S, Dominguez O, Pisano DG, Tarsounas M, Blasco MA (2010). Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites. Nat Cell Biol 12, 768-780.
-TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice
--Tejera AM, Stagno d'Alcontres M, Thanasoula M, Marion RM, Martínez P, Liao C, Flores JM, Tarsounas M, Blasco MA (2010). TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice. Dev Cell 18, 775-789.
-BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping
--Badie S, Escandell JM, Bouwman P, Carlos AR, Thanasoula M, Gallardo MM, Suram A, Jaco I, Benitez J, Herbig U, Blasco MA, Jonkers J, Tarsounas M (2010). BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat Struct Mol Biol 17, 1461-1469.
-p53 Prevents entry into mitosis with uncapped telomeres
--Thanasoula M, Escandell JM, Martinez P, Badie S, Muñoz P, Blasco MA, Tarsounas M (2010). p53 Prevents entry into mitosis with uncapped telomeres. Curr Biol 20, 521-526.
-ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
--McNees CJ, Tejera AM, Martínez P, Murga M, Mulero F, Fernandez-Capetillo O, Blasco MA (2010). ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase. J Cell Biol 188, 639-652.
-SIRT1 contributes to telomere maintenance and augments global homologous recombination
--Palacios JA, Herranz D, De Bonis ML, Velasco S, Serrano M, Blasco MA (2010). SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol 191, 1299-1313.
-Telomere rejuvenation during nuclear reprogramming
--Marión RM, Blasco MA (2010). Telomere rejuvenation during nuclear reprogramming. Curr Opin Genet Dev 20, 190-196.
-2009 nobel prize in physiology or medicine: telomeres and telomerase
--Varela E, Blasco MA (2010). 2009 nobel prize in physiology or medicine: telomeres and telomerase. Oncogene 29, 1561-1565.
-TERRA transcripts are bound by a complex array of RNA-binding proteins
--López de Silanes I, Stagno d´Alcontres M, Blasco MA (2010). TERRA transcripts are bound by a complex array of RNA-binding proteins. Nat Communications 1, 1-9.
-Role of shelterin in cancer and aging
--Martínez P, Blasco MA (2010). Role of shelterin in cancer and aging. Aging Cell 9, 653-666.
-Chromatin regulation and non-coding RNAs at mammalian telomeres
--Schoeftner S, Blasco MA (2010). Chromatin regulation and non-coding RNAs at mammalian telomeres. Semin Cell Dev Biol 21, 186-193.
-The role of telomeres and telomerase in stem cell aging
--Flores I, Blasco MA (2010). The role of telomeres and telomerase in stem cell aging. FEBS Lett 584, 3826-3830.
-Impact papers on aging in 2009
--Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J (2010). Impact papers on aging in 2009. Aging (Albany NY) 2, 111-121.
Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM Jr, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS,
-Telomeres and telomerase in adult stem cells and pluripotent embryonic stem cells
--Marión RM, Blasco MA (2010). Telomeres and telomerase in adult stem cells and pluripotent embryonic stem cells. Adv Exp Med Biol 695, 118-131.
--Marión RM, Strati K, Li H, Murga M, Blanco R, Ortega S, Fernandez-Capetillo O, Serrano M, Blasco MA (2009). A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460, 1149-1153.
-Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells
--Marion RM, Strati K, Li H, Tejera A, Schoeftner S, Ortega S, Serrano M, Blasco MA (2009). Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell 4, 141-154.
-Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice
--Martínez P, Thanasoula M, Muñoz P, Liao C, Tejera A, McNees C, Flores JM, Fernández-Capetillo O, Tarsounas M, Blasco MA (2009). Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. Genes Dev 23, 2060-2075.
-Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations
--Schoeftner S, Blanco R, Lopez de Silanes I, Muñoz P, Gómez-López G, Flores JM, Blasco MA (2009). Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations. Proc Natl Acad Sci USA 106, 19393-19398.
-A 'higher order' of telomere regulation: Telomere heterochromatin and telomeric RNAs
--Schoeftner S, Blasco MA (2009). A 'higher order' of telomere regulation: Telomere heterochromatin and telomeric RNAs. EMBO J 28, 2323-2336.
-MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres
--Martinez P, Siegl-Cachedenier I, Flores JM, Blasco MA (2009). MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres. Aging Cell 8, 2-17.
-Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis
--Ferrón SR, Marqués-Torrejón MA, Mira H, Flores I, Taylor K, Blasco MA, Fariñas I (2009). Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis. J Neurosci 29, 14394-14407.
-TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis
--Muñoz P, Blanco R, de Carcer G, Schoeftner S, Benetti R, Flores JM, Malumbres M, Blasco MA (2009). TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis. Mol Cell Biol 29, 1608-1625.
-Telomere shortening and oxidative stress in aged macrophages results in impaired STAT5a phosphorylation
--Sebastián C, Herrero C, Serra M, Lloberas J, Blasco MA, Celada A (2009). Telomere shortening and oxidative stress in aged macrophages results in impaired STAT5a phosphorylation. J Immunol 183, 2356-2364.
-A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres
--Flores I, Blasco MA (2009). A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres. PLoS ONE 4, e4934-.
Garcia-Lavandeira M, Quereda V, Flores I, Saez C, Diaz-Rodriguez E, Japon MA, Ryan AK, Blasco MA, Dieguez C, Malumbres M, Alvarez CV (2009). A GRFa2/Prop1/stem (GPS) cell niche in the pituitary. PLoS ONE 4, e4815-.
-Genetic dissection of the mechanisms underlying telomere-associated diseases Impact of the TRF2 telomeric protein on mouse epidermal stem cells
--Stout GJ, Blasco MA (2009). Genetic dissection of the mechanisms underlying telomere-associated diseases: Impact of the TRF2 telomeric protein on mouse epidermal stem cells. Dis Model Mech 2, 139-156.

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See also
-Blasco publication text files 02-09-2014d0910
-telopathies