Aging by telomere loss can be reversed
2014-08-29Aging by telomere loss can be reversed
"C:\Users\kurtw_000\Box Sync\DocDR\2014\02-06-2014d0918\Aging by telomere loss can be reversed.pdf"
Abstract
Recently in Nature, Jaskelioff et al. (2010) demonstrated that multiple aging phenotypes in a mouse model of accelerated telomere loss can be reversed within 4 weeks of reactivating telomerase. This raises the major question of whether physiological aging, likely caused by a combination of molecular defects, may also be reversible.
Some notes
- Cell stem cell preview
- CNIO paper
- she mentions Jaskelioff 2010 Nature paper: Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
- -"C:\Users\kurtw_000\Box Sync\DocDR\2014\02-06-2014d0918\Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.pdf"
- -Harvard Medical School papers
- -Harvard telomerase switch
- Tomas-Loba 2008 paper (cancer resistant mice with enhanced telomerase expression)
- -Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice (CNIO paper)
- -"C:\Users\kurtw_000\Box Sync\DocDR\2014\02-06-2014d0918\Telomerase Reversse Transcriptase Delays Aging in Cancer-Resistant Mice.pdf"
- -This is a big paper I missed because I was only looking at papers that were 2009 and after
- q
vators have been reported recently and
have demonstrated some preliminary
health-span bene?cial effects in humans