tail suspension test portal 11-25-2014d2227

2015-04-30

tail suspension test portal 11-25-2014d2227

hold mouse by tail and measure movement

tail suspension test
-http://en.wikipedia.org/wiki/Tail_suspension_test
The tail suspension test paper (Can, Adem et al. “The Tail Suspension Test.” Journal of Visualized Experiments : JoVE 59 (2012): 3769. PMC. Web. 30 Nov. 2014.)
-test usually for 6 min
-http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353516/
--there is a video at that link too
-measure time mice spends struggling
-they use tape (17 cm long fragments) to suspend the mouse. They attach the tail to the middle of the 2 cm portion at the end of the tape.
-they record the mouse
-compounds with antidepressant properties increase the amount of time mice spend struggling. This is reflected by shorter periods of immobility
-multiple mice can be suspended at the same time and recorded
-they do an acclamation period to the room for 1 hr
-they use plastic cylinders around tail to prevent the mouse from climbing its own tail. Their cylinders were 1 cm in diameter, 4 cm long, and 1.5 g.
-typically at the end they graph immobility time
-they don't count the movement if it only involves the front legs

online stopwatch controlled by enter key
http://online-stopwatch.chronme.com/

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