short list of hallmarks of aging and ways to treat them 09-23-2014d1533

2014-09-23

short list of hallmarks of aging and ways to treat them 09-23-2014d1533

Table of Hallmarks of Aging and Ways to Treat Them
"C:\ativ6_storage\projects\cnio\DR\2014\09-23-2014d1535\Table of Hallmarks of Aging and Ways to Treat Them.xlsx"

Which of these (below) would be the most important to combine?
Possible list

TERT gene therapy
young stem cell treatment
overexpression of tumor suppressors
remove senescent cells
overexpression of chaperones
inhibit NF-kappaB (to reduce non-specific inflammation)

Genomic instability
-overexpression of BubR1, a mitotic checkpoint compo-nent that ensures accurate segregation of chromosomes, exhibit an increased protection against aneuploidy and cancer, as well as extended healthy lifespan
-inhibition of NF-kappa B signaling
telomere attrition
-TERT gene therapy
epigenetic alterations
-deletion of components of histone methylation complexes (for H3K4 and for K3K27) (in nematodes and flies) (Greer et al., 2010; Siebold et al.,

2010).

-overexpression of HP1-alpha extends longevity (flies) ((Larson et al.,

2012).) HP1-alpha is involved in chromatin remodelling

-overexpression of SIRT genes (Guarente, 2011)
-specific miRNAs (flies and c. elegans (Liu et al., 2012; Shen et al., 2012; Smith-Vikos and

Slack, 2012))

loss of proteostasis
-overexpress chaperones (Morrow et al., 2004; Walker and Lithgow, 2003)
-increased expression of the protea-some subunit RPN-6 (C. elegans) (Vilchez et al., 2012).
deregulated nutrient sensing
-rapamycin (Johnson et al., 2013)
-inhibit growth hormone receptor (Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice

)

-overexpress Pten or underexpress PI3K (Foukas et al., 2013; Ortega-Molina et al., 2012). These are metabolic genes
mitochondrial dysfunction
-telomere and sirtuin treatments
-hormesis
-metformin (Cabreiro et al., 2013)
-resveratrol (Baur

et al., 2006; Feige et al., 2008; Lagouge et al., 2006; Minor et al.,
2011)

cellular senescence
-removing senescent cells delays aging (Baker et al., 2011 (Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

))

-enhancement of tumor suppressor pathways (Matheu et al., 2007, 2009),
stem cell exhaustion
-transplantation of stem cells (Lavasani

et al., 2012)

-inhibit GTPase CDC42 (Florian et al., 2012)
altered intercellular communication
-administration of anti-inflammatory agents such as aspirin (Rothwell et al., 2011; Strong et al., 2008)
-blood-borne systemic factor GDF11 treatment
-inhibition of NF-kappaB (Adler et al., 2007)
-GnRH treatment (Zhang et al., 2013)
-increase expression of SIRT1 (Xie et al., 2013)
-adjust intestinal bacteria (Claesson et al., 2012; Ottaviani et al., 2011)