paper from sykes 10-13-12
2014-08-29azim58 - paper from sykes 10-13-12
https://mail.google.com/mail/u/0/?shva=1#advanced-search/from=Kathryn.Sykes
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paper location
/home/kurt/Link to 2012/10-13-12/labinvest2011110a.pdf
High-throughput detection of fusion genes in cancer using the Sequenom
MassARRAY platform
recurrent fusion genes/mutations
not sure what they mean by non-modal clone
don't know what FFPE is
FFPE is formalin-fixed, paraffin-embedded
sensitivity vs specificity vs accuracy
These observations lend further support to the suggestion that the
majority of expressed fusion genes in usual types of breast cancer are
private.
approach described is not suitable for the identification of novel fusion
genes and
is of limited utility for discovery studies.
they can only identify transcripts that are displayed at the RNA
transcript level
no recurrent (fusion) events were
identified.
Confirmation of the results with established ‘gold standards,’ such
as FISH and RT–PCR, remains necessary.
Sensitivity measures how well a test identifies disease-positive (D+).
Specificity measures the probability that a positive test result (T+)
correlates to a real D+ person.
http://wiki.answers.com/Q/What_is_the_difference_between_sensitivity_and_sp
ecificity
Sensitivity (also called recall rate in some fields) measures the
proportion of actual positives which are correctly identified as such
(e.g. the percentage of sick people who are correctly identified as
having the condition)
Specificity measures the proportion of negatives which are correctly
identified (e.g. the percentage of healthy people who are correctly
identified as not having the condition)
http://en.wikipedia.org/wiki/Sensitivity_and_specificity