Tau suppression in a neurodegenerative mouse model improves memory function
2015-01-13Tau suppression in a neurodegenerative mouse model improves memory function
some notes
- we examined two lines of mice expressing ~7 and ~13 units of tau
(one unit
is equivalent to the level of endogenous murine tau) (Fig. 1B).
We created transgenic mice expressing mutant tau that could be suppressed with doxycycline
(fig. S1A).
Morris water maze
That memory function improved in =4-month-old mice fed doxycycline despite ongoing
accumulation of NFTs clearly implies dissociation between the processes that lead to memory
loss and those that cause NFTs and that the NFTs remaining after tau suppression are not
sufficient to disrupt cognitive function