Pure text version of aging research timeline for searching 05-30-2014d1648
2015-01-13Pure text version of aging research timeline for searching 05-30-2014d1648
aging research timeline
Event Short Title Year Number for timeline Month
Benjamin Gompertz Finds that Mortality Increases Exponentially with Age Mortality increases with age 1825 0 June
August Weismann proposes a difference between germ line and somatic cells Germ line cells 1892 0 January
Clive McCay Discovers that Calorie Restriction Extends Life-Span in Rats Calorie restriction (McCay) 1934 0 November
Peter Medawar proposes that aging evolved into existence since the force of natural selection diminishes after reproduction No natural selection after reproduction (Medawar) 1952 0 January
Denham Harman proposes the free radical theory of aging Free radical theory 1956 0 July
George C. Williams expands on the theory of antagonistic pleiotropy Antagonistic pleiotropy 1957 0 February
Hayflick and Moorhead Characterize Cellular Senescence in Primary Human Cells Cellular senescence (Hayflick) 1961 0 May
Leslie Orgel proposes the "error catastrophe" theory of aging "Error catastrophe" theory 1963 0 February
Leonard Hayflick proposes the cellular theory of aging based on the limited replicative lifespan of primary human cells Cellular theory of aging (Hayflick) 1965 0 March
David and Harriet Gershon find accumulation of non-active enzymes in older nematodes Accumulation of non-active enzymes 1970 0 September
National Institute on Aging is established NIA is established 1974 0 October
Richard Windruch finds that adult mice on dietary restriction live 20% longer and have lower cancer rates Calorie restriction lower cancer rates (Windruch) 1982 0 March
Anthony Cerami proposes the Maillard Reaction theory of aging stating that DNA accumulates damage due to nonenzymatic modification from sugars Maillard Reaction theory of aging 1983 0 November
Michael R. Rose asserts that senescence can be postponed by natural selection Natural selection for longevity (Rose) 1984 0 February
Carol W. Greider and Elizabeth H. Blackburn discover a specific telomere terminal transferase later known as telomerase Telomerase discovered 1985 0 December
Robert M. Sapolsky, Lewis C. Krey, and Bruce S. McEwen Propose the Glucocorticoid Cascade Hypothesis of Aging Glucocorticoid Cascade Hypothesis of Aging 1986 0 January
Thomas Johnson and David Friedman Define the AGE-1 gene AGE-1 gene 1988 0 February
Cynthia Kenyon finds that mutations in daf-2 and daf-16 genes cause C. elegans worms to live over twice as long Daf-2 and daf-16 mutations 1993 0 September
Brian K. Kennedy et al. Discover that daughter cells of old yeast have shorter life-spans than those of younger strains Daughter cells of old yeast have short lifespans 1994 0 December
Brian K. Kennedy et al. find that SIR4-42 extends life span of yeast by 30% and may play a key role in regulating aging SIR genes involved in longevity (Kennedy) 1995 0 February
Daniel E. Martinez fins that Hydra do not show signs of biological aging Hydra don't age 1997 0 August
Andrea Bodnar, Michel Ouellette, et al. Find an extension of human cell life-span with the introduction of telomerase Telomerase increases human cell life-span 1998 0 January
Simon Melov and Gordon Lithgow use antioxidants to extend the life span of C. elegans Antioxidants extend lifespan (Lithgow) 2000 0 September
Gordon Lithgow links a stress management protein to aging Stress management proteins 2003 0 April
Coleen Murphy et al. find genes downstream of daf-16 which regulate aging in C. elegans nematodes Daf-16 (Murphy) 2003 0 July
David A. Sinclair et al. discover three classes of molecules that activate sirtuins (including resveratrol) Resveratrol activates sirtuins 2003 0 August
Norman Sharpless and Ronald Pinho propose the stem-cell theory of aging Stem-cell Theory 2004 0 January
Laron dwarf mice (Bartke) Laron dwarf mice 2004 0 January
Norman E. Sharpless finds that expression of the Ink4a/Arf locus is a biomarker of aging Ink4a/Arf locus 2004 0 November
Conboy parabiosis experiment shows that a young systemic environment has rejuvenating affects Parabiosis (Conboy) 2005 0 February
Matt Kaeberlein et al. propose that the TOR and Sch9 kinases regulate longevity in yeast TOR 2005 0 November
Brian Kennedy extends lifespan of yeast with rapamycin Rapamycin and yeast (Kennedy) 2006 0 January
Adult cells converted into induced pluripotent stem cells iPSC 2006 0 August
Andrea Bodnar finds a lack of age-associated telomere shortening in long and short lived sea urchins Urchins don't age 2006 0 July
Melov lab shows that strength training exercise reverses aging in human skeletal tissue Strength training 2007 0 May
Melov lab uses biomarkers of aging to predict both chronological and physiological age Biomarkers predict age (Melov) 2008 0 November
Maria Blasco shows that telomerase delays aging in cancer-resistant mice Telomerase cancer Resistant Mice 2008 0 November
SENS Research Foundation founded SENS Foundation 2009 0 March
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Rapamycin and mice (Sharp) 2009 0 July
Zeng lab treats Parkinson's disease in rodents with induced pluripotent stem cells iPSCs and Parkinson's 2010 0 August
DePinho shows that telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice Telomerase reactivation 2011 0 January
Jan M. van Duersen shows that clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders Removing senescent cells increases lifespan 2011 0 November
Maria Blasco shows that telomerase gene therapy increases longevity without increasing cancer Telomerase gene therapy 2012 0 March
Transplanted young stem cells prolong health and lifespan Young stem cells 2012 0 Jan
Google announces Calico R&D biotech company to mitigate and cure aging Calico 2013 0 September
David Sinclair shows that aging is associated with declining NAD+ NAD+ treatment 2013 0 December
Craig Venter starts Human Longevity Inc Human longevity inc 2014 0 March
Amy Wagers shows that systemic GDF11 reverses age-related dysfunction in mice Systemic GDF11 2014 0 May