Possible outline of paper 12-19-2013d1459

2015-01-13

Possible outline of paper 12-19-2013d1459

opinion paper on age associated stem cell autoimmunity theory

Versions of Paper for Immunity & Ageing journal

!MAKE SURE TO CHECK FOR MOST CURRENT VERSION!!

C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-19-2013d1117\versions of age associated stem cell autoimmunity hypothesis paper 12-31-2013d1134

Max length of article can be 1,500.

See this email as a reference: https://mail.google.com/mail/u/0/?ui=2&shva=1#search/srimathy/1433566a6c3acaa2

Current version of collection of documents to send

"C:\Users\KURTW_~1\DOCUME~1\kurt\storage\CIMRES~1\DR\2013\12-19-~1\VERSIO~1\Age Associated Stem Cell Autoimmunity Hypothesis for Immunity and Ageing Journal 12-31-2013d1136.docx"
"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-31-2013d1011\Age associated stem cell autoimmunity figure for journal article 12-31-2013d1145.docx"

Figures
Age Associated Stem Cell Autoimmunity Hypothesis

figure for journal
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-31-2013d1011\Age associated stem cell autoimmunity figure for journal article 12-31-2013d1145.docx"
figure
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-20-2013d1506\Age Associated Stem Cell Autoimmunity Hypothesis Figure 12-20-2013d1535.docx"

Guide for authors for a hypothesis paper

http://www.immunityageing.com/authors/instructions/hypothesis

Abbreviations for paper

"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-31-2013d1011\abbreviations 12-31-2013d1012.xlsx"

Acknowledgements

"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-31-2013d1011\acknowledgements 12-31-2013d1055.xlsx"

References

Style file: "C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-31-2013d1011\biomedcentral.ens"

Possible good journals for age associated stem cell autoimmunity paper

Immunity & Ageing
Autoimmunity reviews
current opinion in Immunology
Journal of Autoimmunity
Stem cell research & Therapy
Stem cell reviews and reports
Cell and tissue research
Theoretical Biology and Medical Modelling
Trends in Immunology

See Comparison of journals for age associated stem cell autoimmunity paper 12-19-2013d1501
"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-19-2013d1117\Comparison of journals for age associated stem cell autoimmunity paper 12-19-2013d1501.xlsx"

Journals in order of preference

Immunity & Ageing
Trends in Immunology
Stem cell reviews and reports
Stem cell research & Therapy
Journal of Autoimmunity

Documents to refer to in order to construct document

Gemini Project Proposal
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\2-2-13\data_download\1100\Gemini Project Proposal Kurt Whittemore.docx"
Dissertation
-C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\kwhittem\Dissertation
Comprehensive Exam document
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\2-2-13\data_download\1100\Role of Immune Recognition of Stem Cells in the Aging Process7.odt"
Another paper I wrote (A microarray method for identifying tumor antigens by screening a tumor cDNA expression library against cancer sera)
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\kwhittem\Papers\My Possible Papers\3p_library\paper\A microarray method for identifying tumor antigens by screening a tumor cDNA expression library against cancer sera.docx"

Essential Ideas and Concepts

bad effects of an aging population
aging, cancer, stem cells, and the immune system
Stem cells and aging
-potential for stem cell therapy (and relation to reliability theory of aging)
-old environment may be unsuitable for stem cells
-stem cells and telomerase
Cancer and aging
-stem cells and cancer cells have many similarities
-Link between telomeres and telomerase to cancer and aging processes
-Cellular senescence theory of aging
--cancer rates increase with age
Immune system and aging
-immune system interacts with cancer, and therefore would affect stem cells and aging process
-autoimmunity increases with age
immune system is less specific and autoimmune diseases increase
-immunosuppression with rapamycin increases lifespan
--point out usual explanation
concept of entropy increasing for both cells and immune system

Hypothesis

possible problem for stem cell therapy if immune system attacks stem cells
immune system could attack stem cells as well as cancer cells

Testing the hypothesis
-compare wound healing rates of immune deficient and wild type mice at young and old stages
-aged stem cells over-proliferate and mis-differentiate
-immune system can recognize and combat tumor cells as evidenced by vaccines
-immune system responds less effectively to vaccines with age
-T cell assay to test whether T cells from old donors target stem cells more than T cells from young donors
--flow cytometry instead (since more information can be acquired0
-wound healing rate symptoms of aging
-measure immune response against several specifically selected stem cell antigens (make sure to include telomerase)
-random peptide array method
-modulation of mouse immune system
--vaccination
--induction of tolerance orally
--induction of tolerance with genetically engineered dendritic cells
-bone marrow transplant to refresh immune system
-apheresis to selectively remove old B and T cells

implications of acquired autoimmune stem cell disease hypothesis