MXD1 in MYC MAX MAD network slide

2015-01-13

MXD1 in MYC MAX MAD network slide

slide
"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2014\03-24-2014d0913\MXD1 in MYC MAX MAD network.pptx"

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The transcriptionally active Max/Myc dimer promotes cell proliferation as well as apoptosis. (PMID 8193530)





MAX (gene) has been shown to interact with:


MXD1 (aka MAD) (PMID 12391307)





MAD binds to MAX and is a transcriptional repressor, and is a candidate tumor suppressor





MXD1 Entrez gene summary


http://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4084


This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.








my summary 


-MYC and MAD compete for MAX


-transcription factors involved in proliferatin, differentiation, and apoptosis


-mutations of MAD involved in cancers