BubR1 notes 4-28-13
2015-01-13azim58 - BubR1 notes 4-28-13
Too much, on the other hand, might be a good thing. In work published
today in Nature Cell Biology, the biologists report that genetically
engineered mice that make extra BubR1 are less prone to cancer. For
example, they found that when they exposed normal mice to a chemical that
causes lung and skin tumors, all of them got cancer. But only 33% of
those overexpressing BubR1 at high levels did.
The animals that overexpressed BubR1 at high levels also lived 15% longer
than controls, on average.