Assessing cell and organ senescence biomarkers paper

2014-08-29

Assessing cell and organ senescence biomarkers paper

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Abstract
A major goal in cancer and aging research is to discriminate the biochemical modifications that happen locally that could account for the healthiness or malignancy of tissues. Senescence is one general antiproliferative cellular process that acts as a strong barrier for cancer progression, playing a crucial role in aging. Here, we focus on the current methods to assess cellular senescence, discriminating the advantages and disadvantages of several senescence biomarkers.

Some notes

Bernardes de Jesus and Maria Blasco paper
CNIO paper
Circulation Research
review paper of senescence biomarkers
Telomere-Dependent Senescence and Aging
there is a nice table of senescent biomarkers
Telomeres as Indicators of Biological Aging
Oncogene-Induced Senescence
Senescence in Myocardial Aging
low-turnover tissues such as the

heart. 1

Novel strategies relying on the mobilization of stem cells and

in the assessment of dysfunctional or senescent cells in the
heart will be valuable approaches for healing the aged heart

Assessing Cellular and Tissue Senescence:

Senescence Biomarkers

Senescence-Associated

-Galactosidase

Senescence-Associated Heterochromatin Foci and

Promyelocytic Leukemia Protein Nuclear Bodies

senescence-associated secretory phenotype (SASP)
Telomere Shortening and DDR
Rb and p53
Other Senescence Biomarkers
q

Senescence
markers ultimately are cancer and aging markers and are
valuable tools for the study of degenerative diseases and
cancer