tumor cDNA library papers 10-14-12

2014-08-29

azim58 - tumor cDNA library papers 10-14-12

Mapping the high throughput SEREX technology screening for novel
**tumor** antigens.
http://www.ncbi.nlm.nih.gov/pubmed/22221053

Identification of a human melanoma antigen recognized by
**tumor**-infiltrating lymphocytes associated with in vivo **tumor**
rejection

http://www.pnas.org/content/91/14/6458.short
This article was from around 1994
This article
Progress in human tumour immunology and immunotherapy
cites that one, and is from 2001
same with this one

A testicular antigen aberrantly expressed in human cancers detected by
autologous antibody screening

from 1997

DNA libraries for the construction of phage libraries: statistical and
structural requirements and synthetic methods.

Engineering antibodies for cancer therapy.

Enhancing cellular cancer vaccines.

http://www.ncbi.nlm.nih.gov/pubmed/20352015

It looks like there are many papers on the SEREX topic. I'm not sure
which would be best to choose.

Identification of human tumor antigens by serological analysis of
recombinant cDNA expression libraries (SEREX).
http://www.ncbi.nlm.nih.gov/pubmed/18432945

Analysis of the B-cell repertoire against antigens expressed by human
neoplasms.
http://www.ncbi.nlm.nih.gov/pubmed/12445280

Potential target antigens for immunotherapy identified by serological
expression cloning (SEREX).
http://www.ncbi.nlm.nih.gov/pubmed/17172736

Identification of tumor-associated autoantigens with SEREX.
http://www.ncbi.nlm.nih.gov/pubmed/15585919

===========================================================================

I think the paper I will choose to read 1st is this one:
Mapping the high throughput SEREX technology screening for novel
**tumor** antigens.
http://www.ncbi.nlm.nih.gov/pubmed/22221053

This journal is only available in print.

So I will read this paper instead
Progress in human tumour immunology and immunotherapy
file:///home/kurt/Link%20to%202012/10-20-12/Progress%20in%20human%20tumour%
0Aimmunology%20and%20immunotherapy.pdf

===========================================================================

no immunity found in one study
transplanted tumour
systems...entail artifactual immunity associated with viral
or chemical induction

IL-2 immune manipulation
IL-2 expands lymphocytes

'reverse immunology'
SEREX

class II restricted antigens

EBV on lymphomas

Wow didn't expect this number
Stoler et al. estimated that about 11,000
genomic alterations occur in a cancer cell,

Table 1 Examples of human cancer antigens

Principles of human cancer antigens

quote
Study of the immune reactivity of patients with melanoma can
identify genes encoding antigens widely expressed on other
tumours (such as breast and prostate cancers). These antigens can
serve as targets for immune attack.

forgot what exactly delayed hypersensitivity is

TILS = tumour-infiltrating lymphocytes

adoptive therapy

whole tumour cells

avipox virus
'naked' DNA

modified peptides (mutated to bind to anchor to HLA better)

Thus, a successful immune reaction
depends on the generation of both CD4+ and CD8+ cells, each of which
are stimulated by unique and separate antigens.

===========================================================================

azim58wiki: