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scFv
2014-08-29
azim58 - scFv scFv stands for single chain fragment variable. This name is derived from the fact that an scFv is produced by combining the light and heavy chain variable regions of an antibody into a single chain. The heavy and light variable regions are combined by a linker. Questions about scFv: * How long is a typical scFv? o The VH,VL and ScFv DNAs were about 340 bp,. 320 bp and 750 bp respectively. - www.wjgnet.com/downpdf.asp?url=/1007-9327/8/258 * What is the linker used in my scFv as of 1-5-12? o scFv Phage Linker 1-5-12 =========================================================================== support that scFv can bind to the same epitopes as the original antibodies can be found in this presentation: "L:\storage\CIM Research Folder\kwhittem\Presentations\2010\10-20-10 Cancer Presentation\Cancer Meeting Presentation 102010.ppt"
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