list of ways that lifespans have been extended

2014-08-29

azim58 - list of ways that lifespans have been extended

List of ways that lifespans have been extended
methods for making organisms live longer

-[dwarf mice 6-20-14]

Overexpression of SIRT3 in HSCs (see Overexpression of SIRT3 in HSCs
2-3-13)

Overexpression of BubR1 to maintain and segregate chromosomes (research
performed initially by Mayo researchers)
http://www.kurzweilai.net/mayo-clinic-study-unmasks-regulator-of-healthy-li
fe-span
http://news.sciencemag.org/sciencenow/2012/12/revved-up-protein-fights-agin
g.html
BubR1 notes 4-28-13

Transgenic overexpression of catalase in mitochondria (mCAT) in mice
increases life span by 20% (5 months) and delays important pathology
(Schriner et al. 2005) in The Biology of Human Longevity by Caleb Finch

Natural selection for longer living traits
"In a now classic paradigm in the experimental evolution of aging, flies
were selected for reproduction at later ages (Rose and Charlesworth,
1980; Rose, 1991). Within 15 generations, this selection regime yielded
flies that lived about 20% longer and had more gradual mortality
acceleration (Luckinbill et al, 1984; Rose, 1984; Rose et al, 2004)

Diet restriction
-Note that diet restriction does not appear to universally increase
lifespan/health. Lab mouse strains do experience an increase in lifespan.
However, wild type mice experience modest if any gains in lifespan from
calorie restriction (The Biology of Human Longevity by Caleb Finch).
Also, some mouse strains actually have shortened lifespans with calorie
restriction such as the DBA/2 strain. Mice also have decreased fertility
with calorie restriction.

simply inject young stem cells into mice
http://news.nationalgeographic.com/news/2012/01/120106-aging-mice-stem-cell
s-old-young-science-health/

parabiotic pairings
A young mouse circulatory system is connected to an old mouse circulatory
system, and compounds in the young mouse system help the old mouse stay
younger. People are trying to figure out what these compounds/factors are.
-paper
Rejuvenation of aged progenitor cells by exposure to a young systemic
environment
Irina Conboy paper
"F:\kurt\storage\CIM Research Folder\DR\2013\4-29-13\parabiotic
pairings.pdf"

block NF-kappaB inflammatory pathway in mice
http://www.kurzweilai.net/scientists-discover-how-to-slow-down-aging-in-mic
e-and-increase-longevity

increase expression of parkin gene for better garbage cleanup
http://www.kurzweilai.net/boosting-cellular-garbage-disposal-can-delay-the-
aging-process-ucla-biologists-report

Rhodiola rosea herb for stress reduction
http://www.kurzweilai.net/herbal-extract-boosts-fruit-fly-lifespan-by-nearl
y-25-percent

here's some life extension lists from others
Twelve Longevity Enhancement Methods Demonstrated in Mice
http://www.fightaging.org/archives/2009/08/a-list-of-interesting-longevity-enhancement-methods-in-mice.php

see also
gerontogenes and longevity genes
-[Table of mouse life extension strategies and amount of life extension 06-14-2014d1439]

azim58wiki: