Threshold level of immunogenicity required

2015-01-13

azim58 - Threshold level of immunogenicity required

I think immunogenicity can be measured through antibody titres and
percent lysis from CTL assays. The values necessary to provide protection
or provide immunogenicity that is high enough above background will
probably vary for each disease.

here is some more info from a quick google search
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025398#pone.0
025398-Lin2
q
As shown by clinical results with the Vi-rEPA vaccine in Vietnam
[13]–[15], a conjugate Vi vaccine appears to meet these criteria and,
in addition, clinical data generated in Vietnam have allowed the
establishment of a serological threshold for clinical protection [13].
ref 13
THE EFFICACY OF A SALMONELLA TYPHI Vi CONJUGATE VACCINE IN
TWO-TO-FIVE-YEAR-OLD CHILDREN

Hib-MenCY-TT Safety and Immunogenicity
http://www.medscape.com/viewarticle/778660_3
q
The proportions of children who, after dose 3, had hSBA titers ≥1:8
(the clinical threshold defined as protective) to serogroups C and Y were
99% and 96%, respectively.[5]

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