Telomerase at the intersection of cancer and aging

2015-01-13

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Abstract
Although cancer and aging have been studied as independent diseases, mounting evidence suggests that cancer is an aging-associated disease and that cancer and aging share many molecular pathways. In particular, recent studies validated telomerase activation as a potential therapeutic target for age-related diseases; in addition, abnormal telomerase expression and telomerase mutations have been associated with many different types of human tumor. Here, we revisit the connection between telomerase and cancer and aging in light of recent findings supporting a role for telomerase not only in telomere elongation, but also in metabolic fitness and Wnt activation. Understanding the physiological impact of telomerase regulation is fundamental given the therapeutic strategies that are being developed that involve telomerase modulation.

Some notes
-Bernardes de Jesus and Maria Blasco paper
-CNIO paper
-Cell review paper
-suggests
 
that
 
can-
cer
 
is
 
an
 
aging-associated
 
disease
 
and
 
that
 
cancer
 
and
aging
 
share
 
many
 
molecular
 
pathways.
 -Telomerase
 
defects
 
may
 
lead
 
to
 
aging
 
and
 
cancer
-Telomerase
 
as
 
a
 
key
 
factor
 
that
 
regulates
 
aging
-Telomerase
 
regulation
 
in
 
cancer
-Telomerase
 
in
 
stem
 
cells
-Therapies
 
based
 
on
 
telomerase:
 
therapeutic
 
value
 
and
future
 
perspectives
-q
It
 
seems
 
hazardous
 
to
 
use
 
the
 
lack
 
of
tumorigenesis
 
in
 
mice
 
as
 
evidence
 
for
 
the
 
safety
 
of
 
pro-
telomerase
 
therapies
 
in
 
humans,
 
because
 
telomerase
 
is
differentially
 
regulated
 
in
 
these
 
organisms
-As
 
a
 
starting
 
point
 
for
 
translating
 
these
 
?ndings
to
 
the
 
clinic,
 
telomerase
 
activation
 
is
 
likely
 
to
 
be
 
tested
 
?rst
for
 
treatment
 
of
 
telomere
 
syndromes
-q
Indeed,
 
a
 
change
 
of
 
paradigm
 
seems
 
to
be
 
occurring
 
in
 
telomerase
 
biology,
 
with
 
a
 
switch
 
from
viewing
 
telomerase
 
as
 
fueling
 
cancer
 
to
 
reversing
 
aging.
-q
Supporting
 
this
 
notion
 
are
 
novel
 
telome-
rase
 
activators
 
[120,127,128],
 
some
 
of
 
which
 
are
 
commer-
cially
 
available
 
and
 
used
 
as
 
anti-aging
 
supplements

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