Telomerase Research Paper by Mara

2015-01-13

azim58 - Telomerase Research Paper by Mara

paper found here
"C:\kurt\storage\CIM Research Folder\DR\2013\3-8-13\Mara telomerase
paper\MBB 491 Maran Sprouse Telomerase Paper-1.docx"

some notes

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key components in aging research: telomeres and telomerase
-also oxidation which wasn't mentioned

Studies have shown that telomeres are degraded by 20-200 base pairs per
round of replication5

leukocyte telomere length is the most widely accepted biological age
marker in humans6

as telomere length decreases so does bone mineral density3.

Significantly shorter leukocyte telomere length has also been associated
with common autoimmune diseases such as rheumatoid arthritis and diabetes8

TERT is a 1132 aa protein

Telomerase is expressed in all cells but not at a high enough
concentration to prevent telomere shortening2.

cancer and dyskeratosis congenita are associated with telomere shortening

Telomere shortening is characteristic of not only ovarian cancer but of
prostate, cervical, breast, colon, lung and pancreatic cancers as
well19-22

In general, early cancer cells have shorter telomeres than normal cells17

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