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Tau suppression in a neurodegenerative mouse model improves memory function

2015-01-13

Tau suppression in a neurodegenerative mouse model improves memory function some notes -we examined two lines of mice expressing ~7 and ~13 units of tau P301L (one unit is equivalent to the level of endogenous murine tau) (Fig. 1B). We created transgenic mice expressing mutant tau that could be suppressed with doxycycline (fig. S1A). Morris water maze That memory function improved in =4-month-old mice fed doxycycline despite ongoing accumulation of NFTs clearly implies dissociation between the processes that lead to memory loss and those that cause NFTs and that the NFTs remaining after tau suppression are not sufficient to disrupt cognitive function
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