Table of mouse life extension strategies and amount of life extension 06-14-2014d1439

2015-01-13

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See also
-[short list of hallmarks of aging and ways to treat them 09-23-2014d1533]

Pure text version of table (may not be updated as frequently; just copy and paste it into excel to see better looking formatting)
Strategy	Percent life extension	Corresponding Paper	Notes
rapamycin (calorie restriction mimetic)	14	Rapamycin fed late in life extends lifespan in genetically heterogeneous mice	
young stem cells	85.7	Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model	These were progerioid mice.  lifespan with treatment: about 65 days; lifespan without treatment: about 35 days (65/35.0*100-100=85.7%)
reactivation of telomerase	-	Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice	They didn't carry out the study long enough to determine how much longer the Tert treated mice lived.  This was from the 2011 Harvard Nature Letter paper.
transgenic tert cancer resistant mice	40.2	Telomerase reverse transcriptase delays aging in cancerresistant mice	transgenic mouse that overexpressed TERT, p53, p16, and p19ARF -> 40.2% median life extension or 50% when considering median life extension; 2008 Cell Maria Blasco paper
TERT gene therapy	24	Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer	telomerase-treated mice, both at 1-year and at 2-year of age, had an increase in median lifespan of 24 and 13%, respectively.  A single AAV9-TERT treatment was performed.  2012 Maria Blasco EMBO paper 
overexpressing BubR1	? Didn't look up	Baker 2013	BubR1, a mitotic checkpoint compo-nent that ensures accurate segregation of chromosomes, exhibit an increased protection against aneuploidy and cancer, as well as extended healthy lifespan
inhibition of NF-kappa B signaling	? Didn't look up	Osorio 2012	
removing senescent cells delays aging	? Didn't look up	(Baker et al., 2011 Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders)	
administration of anti-inflammatory agents such as aspirin	? Didn't look up	(Rothwell et al., 2011; Strong et al., 2008)	
blood-borne systemic factors such as GDF11 treatment	? Didn't look up 	Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle	
Growth hormone receptor inhibition (dwarf mice)	55	Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice	I believe these were transgenic mice
overexpress Pten or underexpress PI3K.  These are metabolic genes	? Didn't look up	 (Foukas et al., 2013; Ortega-Molina et al., 2012).	
tumor supressor pathways	? Didn't look up	(Matheu et al., 2007, 2009)	I don't know if this was performed in mice

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