Pure text version of aging research timeline for searching 05-30-2014d1648

2015-01-13

aging research timeline
Event	Short Title	Year	Number for timeline	Month
Benjamin Gompertz Finds that Mortality Increases Exponentially with Age	Mortality increases with age	1825	0	June
August Weismann proposes a difference between germ line and somatic cells	Germ line cells	1892	0	January
Clive McCay Discovers that Calorie Restriction Extends Life-Span in Rats	Calorie restriction (McCay)	1934	0	November
Peter Medawar proposes that aging evolved into existence since the force of natural selection diminishes after reproduction	No natural selection after reproduction (Medawar)	1952	0	January
Denham Harman proposes the free radical theory of aging	Free radical theory	1956	0	July
George C. Williams expands on the theory of antagonistic pleiotropy	Antagonistic pleiotropy	1957	0	February
Hayflick and Moorhead Characterize Cellular Senescence in Primary Human Cells	Cellular senescence (Hayflick)	1961	0	May
Leslie Orgel proposes the "error catastrophe" theory of aging	"Error catastrophe" theory	1963	0	February
Leonard Hayflick proposes the cellular theory of aging based on the limited replicative lifespan of primary human cells	Cellular theory of aging (Hayflick)	1965	0	March
David and Harriet Gershon find accumulation of non-active enzymes in older nematodes	Accumulation of non-active enzymes	1970	0	September
National Institute on Aging is established	NIA is established	1974	0	October
Richard Windruch finds that adult mice on dietary restriction live 20% longer and have lower cancer rates	Calorie restriction lower cancer rates (Windruch)	1982	0	March
Anthony Cerami proposes the Maillard Reaction theory of aging stating that DNA accumulates damage due to nonenzymatic modification from sugars	Maillard Reaction theory of aging	1983	0	November
Michael R. Rose asserts that senescence can be postponed by natural selection	Natural selection for longevity (Rose)	1984	0	February
Carol W. Greider and Elizabeth H. Blackburn discover a specific telomere terminal transferase later known as telomerase	Telomerase discovered	1985	0	December
Robert M. Sapolsky, Lewis C. Krey, and Bruce S. McEwen Propose the Glucocorticoid Cascade Hypothesis of Aging	Glucocorticoid Cascade Hypothesis of Aging	1986	0	January
Thomas Johnson and David Friedman Define the AGE-1 gene	AGE-1 gene	1988	0	February
Cynthia Kenyon finds that mutations in daf-2 and daf-16 genes cause C. elegans worms to live over twice as long	Daf-2 and daf-16 mutations	1993	0	September
Brian K. Kennedy et al. Discover that daughter cells of old yeast have shorter life-spans than those of younger strains	Daughter cells of old yeast have short lifespans	1994	0	December
Brian K. Kennedy et al. find that SIR4-42 extends life span of yeast by 30% and may play a key role in regulating aging	SIR genes involved in longevity (Kennedy)	1995	0	February
Daniel E. Martinez fins that Hydra do not show signs of biological aging	Hydra don't age	1997	0	August
Andrea Bodnar, Michel Ouellette, et al. Find an extension of human cell life-span with the introduction of telomerase	Telomerase increases human cell life-span	1998	0	January
Simon Melov and Gordon Lithgow use antioxidants to extend the life span of C. elegans	Antioxidants extend lifespan (Lithgow)	2000	0	September
Gordon Lithgow links a stress management protein to aging	Stress management proteins	2003	0	April
Coleen Murphy et al. find genes downstream of daf-16 which regulate aging in C. elegans nematodes	Daf-16 (Murphy)	2003	0	July
David A. Sinclair et al. discover three classes of molecules that activate sirtuins (including resveratrol)	Resveratrol activates sirtuins	2003	0	August
Norman Sharpless and Ronald Pinho propose the stem-cell theory of aging	Stem-cell Theory	2004	0	January
Laron dwarf mice (Bartke)	Laron dwarf mice	2004	0	January
Norman E. Sharpless finds that expression of the Ink4a/Arf locus is a biomarker of aging	Ink4a/Arf locus	2004	0	November
Conboy parabiosis experiment shows that a young systemic environment has rejuvenating affects	Parabiosis (Conboy)	2005	0	February
Matt Kaeberlein et al. propose that the TOR and Sch9 kinases regulate longevity in yeast	TOR	2005	0	November
Brian Kennedy extends lifespan of yeast with rapamycin	Rapamycin and yeast (Kennedy)	2006	0	January
Adult cells converted into induced pluripotent stem cells	iPSC	2006	0	August
Andrea Bodnar finds a lack of age-associated telomere shortening in long and short lived sea urchins	Urchins don't age	2006	0	July
Melov lab shows that strength training exercise reverses aging in human skeletal tissue	Strength training	2007	0	May
Melov lab uses biomarkers of aging to predict both chronological and physiological age	Biomarkers predict age (Melov)	2008	0	November
Maria Blasco shows that telomerase delays aging in cancer-resistant mice	Telomerase cancer Resistant Mice	2008	0	November
SENS Research Foundation founded	SENS Foundation	2009	0	March
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice	Rapamycin and mice (Sharp)	2009	0	July
Zeng lab treats Parkinson's disease in rodents with induced pluripotent stem cells	iPSCs and Parkinson's	2010	0	August
DePinho shows that telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice	Telomerase reactivation	2011	0	January
Jan M. van Duersen shows that clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders	Removing senescent cells increases lifespan	2011	0	November
Maria Blasco shows that telomerase gene therapy increases longevity without increasing cancer	Telomerase gene therapy	2012	0	March
Transplanted young stem cells prolong health and lifespan	Young stem cells	2012	0	Jan
Google announces Calico R&D biotech company to mitigate and cure aging	Calico	2013	0	September
David Sinclair shows that aging is associated with declining NAD+	NAD+ treatment	2013	0	December
Craig Venter starts Human Longevity Inc	Human longevity inc	2014	0	March
Amy Wagers shows that systemic GDF11 reverses age-related dysfunction in mice	Systemic GDF11	2014	0	May

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