Possible outline of paper 12-19-2013d1459

2015-01-13

opinion paper on age associated stem cell autoimmunity theory

Versions of Paper for Immunity & Ageing journal
!!MAKE SURE TO CHECK FOR MOST CURRENT VERSION!!
C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-19-2013d1117\versions of age associated stem cell autoimmunity hypothesis paper 12-31-2013d1134

Max length of article can be 1,500.
-See this email as a reference: https://mail.google.com/mail/u/0/?ui=2&shva=1#search/srimathy/1433566a6c3acaa2

Current version of collection of documents to send
-"C:\Users\KURTW_~1\DOCUME~1\kurt\storage\CIMRES~1\DR\2013\12-19-~1\VERSIO~1\Age Associated Stem Cell Autoimmunity Hypothesis for Immunity and Ageing Journal 12-31-2013d1136.docx"
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-31-2013d1011\Age associated stem cell autoimmunity figure for journal article 12-31-2013d1145.docx"

Figures
Age Associated Stem Cell Autoimmunity Hypothesis
-figure for journal
--"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-31-2013d1011\Age associated stem cell autoimmunity figure for journal article 12-31-2013d1145.docx"
-figure
--"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-20-2013d1506\Age Associated Stem Cell Autoimmunity Hypothesis Figure 12-20-2013d1535.docx"

Guide for authors for a hypothesis paper
-http://www.immunityageing.com/authors/instructions/hypothesis

Abbreviations for paper
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-31-2013d1011\abbreviations 12-31-2013d1012.xlsx"

Acknowledgements
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-31-2013d1011\acknowledgements 12-31-2013d1055.xlsx"

References
-Style file: "C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-31-2013d1011\biomedcentral.ens"

Possible good journals for age associated stem cell autoimmunity paper
-Immunity & Ageing
-Autoimmunity reviews
-current opinion in Immunology
-Journal of Autoimmunity
-Stem cell research & Therapy
-Stem cell reviews and reports
-Cell and tissue research
-Theoretical Biology and Medical Modelling
-Trends in Immunology

See Comparison of journals for age associated stem cell autoimmunity paper 12-19-2013d1501
"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\12-19-2013d1117\Comparison of journals for age associated stem cell autoimmunity paper 12-19-2013d1501.xlsx"

Journals in order of preference
-Immunity & Ageing
-Trends in Immunology
-Stem cell reviews and reports
-Stem cell research & Therapy
-Journal of Autoimmunity

Documents to refer to in order to construct document
-Gemini Project Proposal
--"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\2-2-13\data_download\1100\Gemini Project Proposal Kurt Whittemore.docx"
-Dissertation
--C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\kwhittem\Dissertation
-Comprehensive Exam document
--"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\2-2-13\data_download\1100\Role of Immune Recognition of Stem Cells in the Aging Process7.odt"
-Another paper I wrote (A microarray method for identifying tumor antigens by screening a tumor cDNA expression library against cancer sera)
--"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\kwhittem\Papers\My Possible Papers\3p_library\paper\A microarray method for identifying tumor antigens by screening a tumor cDNA expression library against cancer sera.docx"

Essential Ideas and Concepts
-bad effects of an aging population
-aging, cancer, stem cells, and the immune system
-Stem cells and aging
--potential for stem cell therapy (and relation to reliability theory of aging)
--old environment may be unsuitable for stem cells
--stem cells and telomerase
-Cancer and aging
--stem cells and cancer cells have many similarities
--Link between telomeres and telomerase to cancer and aging processes
--Cellular senescence theory of aging
---cancer rates increase with age
-Immune system and aging
--immune system interacts with cancer, and therefore would affect stem cells and aging process
--autoimmunity increases with age
-immune system is less specific and autoimmune diseases increase
--immunosuppression with rapamycin increases lifespan
---point out usual explanation
-concept of entropy increasing for both cells and immune system

Hypothesis
-possible problem for stem cell therapy if immune system attacks stem cells
-immune system could attack stem cells as well as cancer cells

-Testing the hypothesis
--compare wound healing rates of immune deficient and wild type mice at young and old stages
--aged stem cells over-proliferate and mis-differentiate
--immune system can recognize and combat tumor cells as evidenced by vaccines
--immune system responds less effectively to vaccines with age
--T cell assay to test whether T cells from old donors target stem cells more than T cells from young donors
---flow cytometry instead (since more information can be acquired0
--wound healing rate symptoms of aging
--measure immune response against several specifically selected stem cell antigens (make sure to include telomerase)
--random peptide array method
--modulation of mouse immune system
---vaccination
---induction of tolerance orally
---induction of tolerance with genetically engineered dendritic cells
--bone marrow transplant to refresh immune system
--apheresis to selectively remove old B and T cells

-implications of acquired autoimmune stem cell disease hypothesis

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