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Mention of DEAD box on website 11-19-12

2015-01-13

azim58 - Mention of DEAD box on website 11-19-12 http://www.nature.com/nrc/journal/v12/n11/full/nrc3388.html q Using the 4T1 mouse model of mammary tumour progression (a set of cell lines with a range of metastatic abilities when implanted in syngeneic mice), Dardenne et al. first observed overexpression of the DEAD box RNA helicase DDX17 in cells that are more likely to give rise to metastases (4T1 cells) compared with non-metastatic 67NR cells. DDX17 and its paralogue DDX5 often have redundant functions, and knocking down expression of either or both with small interfering RNAs (siRNAs) inhibited in vitro migration and invasion of 4T1 cells. DDX17 and DDX5 are known to regulate alternative splicing, and the authors found that DDX17 and DDX5 regulated the exon abundance of many genes that encode chromatin or DNA-binding factors.
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