MXD1 in MYC MAX MAD network slide

2015-01-13

slide
"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2014\03-24-2014d0913\MXD1 in MYC MAX MAD network.pptx"

some powerpoints this slide is found in
-C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\kwhittem\Presentations\2014\PhD Oral Defense\Oral Defense Presentation Kurt Whittemore 4-11-14.pptx
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2013\4-3-13\General Meeting Presentation 4-3-13\General Meeting Presentation 4-3-13.pptx"

Text on slide
{
The transcriptionally active Max/Myc dimer promotes cell proliferation as well as apoptosis. (PMID 8193530)

MAX (gene) has been shown to interact with:
MXD1 (aka MAD) (PMID 12391307)

MAD binds to MAX and is a transcriptional repressor, and is a candidate tumor suppressor

MXD1 Entrez gene summary
http://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4084
This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

my summary 
-MYC and MAD compete for MAX
-transcription factors involved in proliferatin, differentiation, and apoptosis
-mutations of MAD involved in cancers

}

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