Genomic instability in iPS time for a break

2015-01-13

"C:\Users\kurtw_000\Box Sync\DocDR\2014\02-05-2014d1656\Genomic instability in iPS time for a break.pdf"

Abstract
The discovery of a simple protocol capable of generating
pluripotent stem cells from terminally differentiated cells
has been one of the most promising breakthroughs in
recent biomedical research. Since their discovery, manu-
scripts characterizing properties of induced Pluripotent
Stem (iPS) have ﬂooded the literature. Among others, the
analysis of the transcriptome and epigenome of iPS is now
a recurrent theme that is helping to understand the
molecular mechanisms behind reprogramming. Recent
works have revealed that transcriptional and epigenetic
reprogramming is often incomplete, which has raised
some concerns on the nature of iPS. Inevitably, now the
genome itself of iPS has been scrutinized; and the reports
come with an unexpected twist: the presence of mutations
in the genome of iPS.

Some notes
-CNIO paper
-I think this is kind of a review paper
-q
unexpected twist: the presence of mutations
in the genome of iPS.
-
EMBO European Molecular Biology Organization journal
-initial pictures of the iPS genomes have revealed
the presence of worrisome abnormalities in these cells, which
should be seriously considered for the future

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