Assessing cell and organ senescence biomarkers paper

2014-08-29

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Abstract
A major goal in cancer and aging research is to discriminate the biochemical modifications that happen locally that could account for the healthiness or malignancy of tissues. Senescence is one general antiproliferative cellular process that acts as a strong barrier for cancer progression, playing a crucial role in aging. Here, we focus on the current methods to assess cellular senescence, discriminating the advantages and disadvantages of several senescence biomarkers.

Some notes
-Bernardes de Jesus and Maria Blasco paper
-CNIO paper
-Circulation Research
-review paper of senescence biomarkers
-Telomere-Dependent Senescence and Aging
-there is a nice table of senescent biomarkers
-Telomeres as Indicators of Biological Aging
-Oncogene-Induced Senescence
-Senescence in Myocardial Aging
-low-turnover tissues such as the
heart. 1
-Novel strategies relying on the mobilization of stem cells and
in the assessment of dysfunctional or senescent cells in the
heart will be valuable approaches for healing the aged heart
-Assessing Cellular and Tissue Senescence:
Senescence Biomarkers
-Senescence-Associated
-Galactosidase
-Senescence-Associated Heterochromatin Foci and
Promyelocytic Leukemia Protein Nuclear Bodies
- senescence-associated secretory phenotype (SASP)
-Telomere Shortening and DDR
-Rb and p53
-Other Senescence Biomarkers
-q
Senescence
markers ultimately are cancer and aging markers and are
valuable tools for the study of degenerative diseases and
cancer

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