Aging by telomere loss can be reversed

2014-08-29

"C:\Users\kurtw_000\Box Sync\DocDR\2014\02-06-2014d0918\Aging by telomere loss can be reversed.pdf"

Abstract
Recently in Nature, Jaskelioff et al. (2010) demonstrated that multiple aging phenotypes in a mouse model of accelerated telomere loss can be reversed within 4 weeks of reactivating telomerase. This raises the major question of whether physiological aging, likely caused by a combination of molecular defects, may also be reversible.

Some notes
-Cell stem cell preview
-CNIO paper
-she mentions Jaskelioff 2010 Nature paper: Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
--"C:\Users\kurtw_000\Box Sync\DocDR\2014\02-06-2014d0918\Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.pdf"
--Harvard Medical School papers
--Harvard telomerase switch
-Tomas-Loba 2008 paper (cancer resistant mice with enhanced telomerase expression)
--Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice (CNIO paper)
--"C:\Users\kurtw_000\Box Sync\DocDR\2014\02-06-2014d0918\Telomerase Reversse Transcriptase Delays Aging in Cancer-Resistant Mice.pdf"
--This is a big paper I missed because I was only looking at papers that were 2009 and after
-q
 small molecule telomerase acti-
vators have been reported recently and
have demonstrated some preliminary
health-span bene?cial effects in humans

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