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AAV adeno-associated virus vector 10-05-2014d1503

2014-10-05

AAV adeno-associated virus vector 10-05-2014d1503 how much dna can be put into an aav? -Eduard Ayuso recommends (for AAV9) that the gene cDNA should be less than 4 kb, and then a tag and promoter should be added so his recommendation matches well with vector biolabs -about 4.7 kb according to vector biolabs. However, since the two ITRs of AAV is about 0.2-0.3Kb in total, the foreign DNA that could be introduced between these 2 ITRs should be <4.4Kb, which is much smaller than that of recombinant adenovirus (7.5Kb). --http://www.vectorbiolabs.com/vbs/page.html?m=262 -I could also look at Gene Therapy Using Adeno-Associated virus vectors -Effect of Genome Size on AAV Vector Packaging
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