p53 portal 10-05-2014d1340 q The function of p53 is to prevent cellular proliferation in the face of cellular damage (Vogelstein et al., 2000). The Tp53 website http://p53.free.fr/index.html s: can too much p53 be bad? -What happens when your p53 genes are overaggressive? --http://www.sharecare.com/health/genetics-genetic-disorders/p53-too-aggressive ---From the book: You: staying young: the owner's manual for extending your warranty ---q: Sometimes p53 can become overstimulated and halt replication in your progenitor cells (another name for your adult stem cells), which is a bad thing—especially when you're older and don't have as many progenitor cells to help revitalize your organs. ---q: In rats with elevated p53 action, for example, life expectancy is 20 percent shorter, and it also comes with a side order of old-age symptoms like muscle atrophy, thin skin, and hunched backs. ---q (from the book, not the webpage): Li-Fraumeni syndrome. People with this rare syndrome have a mutant p53 gene-it's like having their guard dog asleep at the gate. Half the people with this syndrome develop cancer by age thirty, compared to 1 percent of the regular population ---q (from the book, not the webpage): In the grand scheme of aging, our ultimate goal may be to strike a balance so that we can turn down our p53s a notch or two; just enough to reduce the risks of frailty that come with an overactive one, but not so much as to leave us at an increased risk of developing cancer -p53 and ageing: too much of a good thing? --http://www.ncbi.nlm.nih.gov/pubmed/12111716 --article behind paywall I can't get past -[Delayed ageing through damage protection by the Arf/p53 pathway] -Cellular and organismal ageing: Role of the p53 tumor suppressor protein in the induction of transient and terminal senescence. -Aging or tumor: the crosstalk between telomerase and p53 (article in Chinese) -p53 good cop bad cop -wikipedia quote: excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer -wikipedia q: p53 prevents the cell from replicating by stopping the cell cycle at G1, or interphase, to give the cell time to repair, however it will induce apoptosis if damage is extensive and repair efforts fail. Any disruption to the regulation of the p53 or interferon genes will result in impaired apoptosis and the possible formation of tumors. -Can Cinnamon Fight Cancer? --http://www.life-enhancement.com/magazine/article/1164-can-cinnamon-fight-cancer --Too much p53 can interfere with the normal and necessary process of cellular reproduction, thereby accelerating the aging process. Laboratory animals with enhanced expression of the p53 gene have fewer cancers, but they tend to die young from “old age.” -[Super p53 mice exhibit enhanced DNA damage response are tumor resistant and age normally] p53 review paper - New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy -p53 at the crossroads between cancer and neurodegeneration -Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis -Live or let die: the cell's response to p53 -Recent Advances in p53 Research and Cancer Treatment -The P53 pathway: what questions remain to be explored? -p53: structure, function and therapeutic applications -p53: guardian of the genome and policeman of the oncogenes -The p53 pathway paper 1999 Arol Prives -Two faces of p53: aging and tumor suppression domains in p53 TAD = transactivation domain PrD = proline domain NLS = nuclear localization signal OD = oligomerization domain BR = basic region Promoters p53 can bind to (this is for human I think) Mdm2 Bax -[sequences for mouse p53 isoforms 10-16-2014d1457] --------------------- see also -[p53 gene therapy portal 10-02-2014d1437] -[isoforms of p53 10-07-2014d1414] -[p53 mouse promoter 10-07-2014d1415] -[mouse p53 sequence information 10-05-2014d2315]