number of unique antibodies in blood size of antibody repertoire size of B cell population number of B cells in lymphocyte population I made a bionumbers page of this -http://bionumbers.hms.harvard.edu/bionumber.aspx?&id=110381 -10^10. . ."At any given time, the serum antibody repertoire of an individ- ual contains ~1010 antibody speci?cities consisting of basal levels of low af?nity near germline antibody clones, along with af?nity matured clones that re?ect an individual’s immunological history." --A general method for characterization of humoral immunity induced by a vaccine or infection -10^11. . ."The combinatorial association of such stochastically generated light and heavy chains has the potential to generate many orders of magni- tude more diversity than can be uniquely displayed on the 10 11 B-cells in a single individual’s lymphocyte population (2,8)" --this quote is from this paper: "Precise determination of the diversity of a combinatorial antibody library gives insight into the human antibody repertoire" --reference 2 is to "Theoretical studies of clonal selection Minimal antibody and reliability of self-non-self discrimination", but from a quick scan I did not find the 10^11 number --reference 8 "Number and distribution of lymphocytes in man" seems to be inaccessible. Perhaps it is too old (1974 or something) and it is from Germany --------- See also -[Number of Immunoglobulin G molecules in 1 ml of serum] -[How many antibodies are in the body_]