human vaccines slide 03-24-2014d1548

slide
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2014\03-24-2014d0913\human vaccines slide 2 03-24-2014d1548.pptx"
-"C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\DR\2014\03-24-2014d0913\human vaccines slide 03-24-2014d1548.pptx"

some powerpoints this slide is found in
-C:\Users\kurtw_000\Documents\kurt\storage\CIM Research Folder\kwhittem\Presentations\2014\PhD Oral Defense\Oral Defense Presentation Kurt Whittemore 4-11-14.pptx


some text from slide
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Summary Points
-Penny Gwynne and the Peptide Array Core performed experiments
-expect entropy to decrease post vaccination after enough days have passed
-CIM10Kv2 random peptide arrays used
-entropy decreased if the time was more than 3 days


Some text from dissertation about this info
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The previous section demonstrated that changes in the AbStat measures can be observed when a mouse is vaccinated, but do the same results hold when a human is vaccinated?  If the results do hold true, then this means that the AbStat measures can be used to detect when there is a sudden and strong immune response in humans.  This issue was explored by applying sera from humans pre and post vaccination to the peptide microarray and analyzing the AbStat results.  The expectation is that the entropy of the fluorescence intensity distribution will decrease post vaccination after enough days have passed.
Penny Gwynne collected sera from two individuals identified as individual 84 and individual 43 around the time when they received the seasonal flu vaccine.  The Peptide Array core under the direction of Zbigniew Cichacz then applied the sera to the CIM10Kv2 random peptide arrays.  The fluorescence intensity distribution was then characterized.  Two line graphs of the entropy over time are displayed for individual 43 for the flu vaccine they received in 2006 and 2009 in Figure 24 and Figure 25.  A line graph of the entropy over time for individual 84 for the flu vaccine they received in 2009 is displayed in Figure 26.
Figure 24 Change in entropy after vaccination for individual 43 in December 2006
Figure 25 Change in entropy for individual 43 in December 2009
 
 
Figure 26 Change in entropy after vaccination for individual 84 in December 2009

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